Knock-Out Mice Reveal a Critical Antiepileptic Role for Neuropeptide Y
نویسندگان
چکیده
منابع مشابه
Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.
Neuropeptide Y (NPY) inhibits excitatory synaptic transmission in the hippocampus and is implicated in control of limbic seizures. In the present study, we examined hippocampal function and the response to pharmacologically induced seizures in mutant mice lacking this peptide. In slice electrophysiology studies, no change in normal hippocampal function was observed in NPY-deficient mice compare...
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A role for neuropeptide Y (NPY) in neurotransmission in rat iridial arterioles has been investigated. Reverse transcription-polymerase chain reaction analysis has demonstrated mRNA expression for both Y1 and Y2 receptors in the superior cervical ganglion and iris. The Y1agonist [Leu31,Pro34]NPY caused a dose-dependent constriction of iris arterioles (50% effective concentration of 10-8 M), but,...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1997
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.17-23-08927.1997